In the years since schizophrenia was discovered, researchers have been working hard to determine the underlying biological mechanisms that cause the illness. The team says their findings may explain why schizophrenia tends to develop in late adolescence or early adulthood; excessive synaptic pruning caused by increased C4 activity at this point in time may trigger symptom onset. Since our 2015 review of this literature, multiple new studies have been published using these techniques. They aim to find out more about how C4 contributes to synaptic pruning, and to determine whether such pruning may play a role in other neurological conditions. Professor Shannon Weickert is encouraging a cross-collaborative approach between neuroscientists and immunologists globally, to work together to develop treatments targeting this abnormal immune pathology of schizophrenia. Next, the team hopes to create mouse models with the human C4 variants associated with schizophrenia risk. “This breakthrough demonstrates the value of the NSW Government’s support for Professor Shannon Weickert as NSW Chair of Schizophrenia Research, which has delivered new insights that the community seeks,” said Professor Schofield. The illness was first discovered by German psychiatrist Dr. Emile Kraepelin in 1887, though the term “schizophrenia” was not used until 1910, coined by Swiss psychiatrist Paul Eugen Bleuler. Explore and learn more about related title Schizophrenia Bulletin Open, an online-only, fully Open Access journal publishing in 2020. A gene called C4 plays a key role in schizophrenia development, new research finds, representing the first ever study to shed light on the biological origins of the mental illness. “We’re far from having a treatment based on this,” she adds, “but it’s exciting to think that one day we might be able to turn down the pruning process in some individuals and decrease their risk.”. To download the journal article and digital files click here. “The same proteins are doing one thing in the periphery for immunity, and another thing in the brain,” says McCarroll. Shares of Alkermes are up nicely after positive data from its schizophrenia drug trial. The results may also explain why some people with schizophrenia have a thinner cerebral cortex with fewer synapses. Better heart health in midlife may lower dementia risk, Male bosses regard employee depression more negatively, Debra Sullivan, Ph.D., MSN, R.N., CNE, COI. Learn more about possible causes and their treatment options here. Schizophrenia Research Breakthrough: Gene That Increases Risk Of Disorder Could Lead To New Therapies Jan 27, 2016 03:32 PM By Ali Venosa @AliVenosa Is the cause of schizophrenia just locked in our DNA? In Schizophrenia’s Wake, a Son Laments the Father Who Might Have Been Emerson Hart is a singer-songwriter. 16, 2020 — Scientists have conducted the largest-ever whole genome sequencing study of schizophrenia to provide a more complete picture of the role … SIRS 2019 Abstracts. Schizophrenia is a mental disorder characterized by hallucinations, delusions, dysfunctional thought processes and agitated body movements. “These results show that it is possible to go from genetic data to a new way of thinking about how a disease develops – something that has been greatly needed.”, For some people, wearing headphones may aid sleep. Scientists make schizophrenia breakthrough. Find out also how an…, Rett syndrome (RTT) is a rare genetic condition that results in mental and physical disabilities. Breakthrough symptoms can include voices, delusions, paranoia, anxiety, or other depressive features. Breakthrough in schizophrenia identifies importance of immune cells 13 Sep 2018 Researchers from NeuRA and UNSW have made a major discovery in schizophrenia research that could open doors to new treatments, research and therapies. Schizophrenia is a serious mental disorder in which people interpret reality abnormally. Cardiff University researchers make schizophrenia breakthrough . It is estimated that around 21 million people across the globe have schizophrenia, with symptom onset most common in late adolescence or early adulthood. “In this area of science, our dream has been to find disease mechanisms that lead to new kinds of treatments,” says McCarroll. It offers new insights into the biological causes of schizophrenia . The drug, which the FDA granted a breakthrough therapy designation in 2019, is currently being evaluated for safety in the Developing Innovative Approaches for … “We have observed in people with schizophrenia, … Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional, Understanding the genetic roots of schizophrenia, identified more than 100 areas of the human genome, Specific C4 structures linked to increased schizophrenia risk, C4 ‘prunes’ synapses to increase schizophrenia risk, A ‘crucial turning point in the fight against mental illness’, Through my eyes: Adjusting to life with a spinal cord injury. It almost entirely affects females. By 2020, schizophrenia will most likely still be a clinically defined primary psychotic disorder. Read our COVID-19 research and news. In July 2014, the Schizophrenia Working Group of the Psychiatric Genomics Consortium – including investigators from the Stanley Center – identified more than 100 areas of the human genome that are linked to the disorder. The Breakthrough Schizophrenia Treatments You Need to Know About From long-lasting Injectables to a whole new drug class, here are the five most important cutting-edge treatments. Published. Hallucinations Research: Into the Future, and Beyond. THURSDAY, April 16, 2020 (HealthDay News) -- An experimental drug may ease a range of symptoms that strike people with schizophrenia, without the … Apr. Learn about the symptoms of anxiety, including when they might occur, what causes them, and what you can be do about them. NeuRA Media Department +61(0)409225447 or media@neura.edu.au, Katrina Usman +61(0)432760940 or k.usman@neura.edua.au. By James Gallagher Health reporter, BBC News. In some cases, the person is already symptomatic, and due to being exposed to an extremely traumatic experience, an existing mental health condition becomes exacerbated and symptoms intensify. According to the statistics nearly 100,000 Australians have psychosis. Hand weakness can occur due to many different health conditions. The team was surprised by their results; they found that specific C4 gene structures could predict C4 gene activity in the brain. Symptoms may come and go, but schizophrenia requires lifelong treatment. What does loneliness look like in the brain? In what has been hailed a “breakthrough” in schizophrenia research, scientists from Harvard Medical School, the Broad Institute and Boston Children’s Hospital – all in Massachusetts – have discovered how a gene called complement component 4 (C4) plays a key role in schizophrenia development. 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